Celiac with MTHFR defect and other genetic anomalies that make breaking down b vitamins difficult. I have been exhausted (seriously medically diagnosed with chronic fatigue) and I was very doubtful that changing my vitamin b type would do anything. Cynical skeptical whatever that was me. I took it dutifully every morning for about 2 weeks before I noticed that I wasn't nearly as exhausted by noon needing a 2 hour nap just to make it to bedtime. Enter life – busy Mom life and the pace picked up – kid with concussion lots of appointments, coordinating with his school, taxi back and forth for 30 minute school days, other kid with special needs daily life gets really really busy and I have been able to keep up without naps – UNTIL – 3 days ago I got so busy in the morning rush I forgot to take my morning Black Bear sprays and by 1 pm I hit my wall and sadly had to stop in the middle of everything to catch a 30 minute mini nap. It took me a bit to figure it out but when I realized that I had forgotten it I thanked my lucky stars that it had been working so well. I will not make that mistake again. I am happy to report the huge change in my energy level, it's so nice to have a normal level of energy again I was kinda lost in my own blissful ignorance, once again enjoying the fast pace of normal life. Thanks from a customer for life!!!